THC-O (Tetrahydrocannabinol-O-acetate), also known as THCO or THC-O acetate, is a synthetic cannabinoid derived from hemp
. It's a man-made compound, not found naturally in the cannabis plant.
Here's a breakdown of what THCO is:

• Synthetic origin: THCO is produced in a laboratory through a process that typically starts with extracting CBD (cannabidiol) from hemp. This CBD is then converted into Delta-8 THC, which is then acetylated (mixed with acetic anhydride) to create THC-O. The process involves hazardous chemicals and requires specialized equipment, according to recovered.org.

• Potency: THCO is reported to be significantly more potent than Delta-9 THC (the main psychoactive compound in marijuana), with some sources suggesting it's two to three times stronger. This increased potency may be due to its enhanced ability to cross the blood-brain barrier after acetylation.

• Psychoactive Effects: THCO produces a high similar to other forms of THC but potentially more intense and longer-lasting. Users have reported euphoria, relaxation, and potential alterations in sensory perception. Some anecdotal evidence suggests THCO might have psychedelic-like effects, but research indicates these claims may be exaggerated.

• Prodrug: THCO is considered a prodrug, meaning its psychoactive effects are not felt until it's metabolized by the body (specifically, the liver). This leads to a delayed onset of effects, which can be a safety concern as users might take a second dose before feeling the initial effects, potentially leading to overconsumption.

• Legal Status: The legality of THCO in the United States is complex and contested. The DEA has stated it's a controlled substance because it's synthetically derived and not naturally occurring in hemp. However, some argue that the 2018 Farm Bill, which legalized hemp and its derivatives (containing less than 0.3% Delta-9 THC), could include THCO since it's derived from hemp. A U.S. Court of Appeals for the Fourth Circuit ruled in 2024 that THCO meets the legal definition of hemp, but the legal landscape remains uncertain.

• Safety Concerns: There is limited research on the long-term effects and safety of THCO. Concerns have been raised about the potential for harmful by products during its production, especially when heated for vaping or dabbing, as it can produce ketene, a toxic substance linked to lung injuries. The lack of regulation also raises concerns about product quality and contamination.

Important Note: Given the limited research and potential risks, it is essential to approach THCO with caution. It is crucial to be aware of the laws in your specific location and to seek professional guidance if you are considering using this or any other cannabinoid product.